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The desire to have a journal, which eventually was named Toxicology Digest, came after series of successful gatherings of the West African Society of Toxicology (WASOT). The major aim of the journal includes reporting original research papers emanating from the use of sound scientific techniques in providing solutions to the myriad of problems facing Toxicologists. Therefore, we intend to capture latest and important information in the main areas of Toxicology specifically Mechanistic Toxicology, Descriptive Toxicology, Regulatory Toxicology and Risk Assessment. The ultimate aim of having this journal is to present to the world a journal that will position Africa especially the West African region in the forefront of research with enhanced visibility in Toxicology. It is hoped that the journal will enhance the quality of toxicologists in academia, government and industry with a view to influencing policy/decision making, research development and management of toxic chemicals in the face of rapid industrialization.
It is therefore with great delight to present this maiden issue of Toxicology Digest. It is our utmost desire to make Toxicology Digest one of the foremost journals in Africa and we eagerly look forward to receiving original contributions from Toxicology researchers in the various areas of the discipline. Happily, we have received tremendous support from experts outside the country and actually we have a paper from one of the leading Toxicologists in the world in this maiden edition. Therefore, as we endeavor through collective effort to raise the standard and quality of the journal, international experts in the field will be encouraged to contribute regularly to the journal. By this arrangement, it is anticipated that the quality of researchers in Toxicology within the region will be impacted and enhanced and at the same time the entire world will have access to first hand information about Toxicology problems in Africa particular the West African zone thereby bridging the academic gap between Africa and the world and fill the lacuna existing in the field of Toxicology.
Using embryonic stem cell model of lead exposure during neural differentiation and DNA methylation analyses, Sánchez-Martín and Puga presented developmental mechanisms of lead neurotoxicity. Anetor and other colleagues reviewed the ‘Cancer villages’ in China as toxicological pathways for introducing toxic materials into the Nigerian environment and recommended that Nigeria should thread the path of cautionary principle to avert the emergence of mega ‘cancer villages’. Anetor and others presented the Zamfara Lead poisoning episode in Nigeria as an indication for exposure of children to environmental toxicants and emphasized the need for a micronutrient centre. Folorunsho et al presented a review on on Artemia salina L. hatching methods and lessons for the Nigerian Ecotoxicologist. Ezechi and Onwurah reported the Layer performance and egg quality of poultry birds exposed to dichlorvos, a synthetic organophosphate pesticide used in the control of household and agricultural pests and emphasized that exposure of laying hens to dichlorvos could affect the reproductive success of the hens. The article of Onyenekwe et al on comparative evaluation of Alstonia boonei and Sphenocentrum jollyanum on high fat diet induced obesity in male Wistar rats demonstrated that fractions from A. boonei and S. jollyanum showed varying potentials to reduce weight and reduction of oxidative stress and fat deposition in the liver of rats fed high fat diets and A. boonei stem bark showed more promising antiobesity potential than that of S. jollyanum in rats fed high fat diets. Oparaji and others evaluated in a rodent model the sub-chronic toxicity of Khaya senegalensis acetone stem bark extract and that the extract has implication in myocardial and skeletal muscle injury. Omotosho et al investigated the interplay of trace elements with cytokines in fourteen hypertensives and discussed the possible pathological implication of this in the development and progression of hypertension. Free radical- induced damage in Clarias gariepinus, a fish model for evaluating toxicity was reported by Arojojoye and Farombi as municipal landfill leachate could pose potential danger to aquatic species and humans. Olorunfemi et al correlated toxicity with Bilge water exposure in African Catfish [Clarias gariepinus (Burchell, 1822)] Juveniles. Ikoyo-Eweto et al reported the Effects of low pH and iron toxicity on survival of Oreochromis niloticus and lowland NERICA rice seedlings. Omotosho and Ogunsiji revisited cadmium and lead contents of some cigarettes in Nigeria and emphasized standardization in processing. Babatunde et al evaluated human health hazards from consumption of seas foods and vegetables, from Port Harcourt, Nigeria containing trace metals and recommended coordinated monitoring exercise against public health impact. Babatunde and others evaluated the relative amount of Pharmaceutical and Personal Care Products and paracetamol residues contained in household waste at the University of Port Harcourt, Port Harcourt, Nigeria and recommended appropriate channel routes for disposing of unused or expired drugs. Anwa-Udondiah and Okoro presented the outcome of the water chemistry from the case studies and juxtaposed them with water parameters from a fish hatchery.
In this maiden issue of Toxicology Digest, the editorial board selected research articles from a list of papers submitted. In the subsequent issues we hope to publish other articles. Though it took some time before producing this maiden edition due to some teething problems expected of a new journal, we look forward to receiving interesting articles in form of reviews, commentaries, research articles and case reports in various areas of Toxicology from your research groups and we hope to publish them timely.
I like to thank the Advisers of WASOT and the Executive ably led by President OE Orisakwe for giving me the opportunity to serve as the first Editor-in-Chief of Toxicology Digest. I thank the members of the editorial team especially Dr. Babatunde for working so hard to ensure the production of this maiden edition. I specially thank our international advisers for their support, encouragement and numerous contributions. Thanks to our esteemed reviewers who sacrificially accepted to review all the articles published in this maiden edition.
Ebenezer O. Farombi, PhD, FRSC, ATS, FAS, FAAS
Professor of Biochemistry and Molecular Toxicology